We will take a look at the pathophysiology (root cause) of gynecomastia in this part of the Gynexin review. A medical condition, abuse of drugs, carried over excess estrogens from adolescence or other unknown causes creates excessive levels of estrogen in the male body and changes the estrogen-tesosterone balance . When the male body has excessive levels of estrogen, it leads to two important reactions. First, it encourages the body to retain more fat in the breasts and in the abdomen. Second, the male hormone testosterone levels are significantly reduced . This is the preparatory stage of breast tissue growth. In the next stage, the chest fat produces an enzyme called aromatase that converts estrogen to testosterone and acts as a secondary gland that produces estrogen and more estrogen is produced along with suppression of male hormone testosterone . So excess estrogen, pectoral fat and low testosterone levels form a negative feedback loop where estrogen and chest fat feeds each other. This is how we develop gynecomastia .
Gynecomastia should always be diagnosed by a doctor and never self-diagnose it. Your family doctor or a general physician can do a physical examination and confirm it is best to see a doctor who specialises in gynecomastia treatment and surgery. These are medical professionals who see men with gynecomastia on a daily basis and there is absolutely nothing you have to be ashamed of in seeing a doctor. Almost all gynecomastia doctors offer an initial complimentary consultation and I encourage you to make use of that opportunity. Diagnosing will also give you an idea of what proportion of breast enlargement is breast tissue and what proportion is chest fat. Below is an illustration of one way a doctor may diagnose gynecomastia.
The patient lies flat on his back with his hands clasped beneath his head. Using the separated thumb and forefinger, the examiner slowly brings the fingers together from either side of the breast. In patients with true gynecomastia, a rubbery or firm mound of tissue that is concentric with the nipple–areolar complex is felt. In patients with pectoral or chest fat or pseudogynecomastia, no such disk or tissue is found .
|Gynecomastia or Breast Tissue||Pseudogynecomastia or Chest Fat|
|A mass under the nipple area of the breast with or without pain when touched or squeezed.||Breast enlargement involves the both breasts equally and evenly, without pain during palpation.|
Again, do not self-diagnose it for two reasons. First, the above illustration and diagnosis approach was given to you for information purposes only and you cannot for sure say what you have is in fact, gynecomastia until it has been confirmed by a doctor. The second reason is to avoid confirmation bias which is the tendency to interpret possible evidence as confirmation of one’s existing beliefs. So if you have already confirmed that what you have is gynecomastia, there is a high chance of error if you self-diagnose. The bottom line is that do not self-diagnose it and always have a doctor do it for you.
We will take a look at the history of gynecomastia supplements in this part of the Gynexin review and this will help you see the path that led to development of Gynexin. In the 1960’s and 1970’s scientists developed drugs that can prevent the process of aromatisation. Aromastisation is the process by which male hormone testosterone is converted to estrogen through the enzyme aromatase. There are two classes of drugs that influences estrogen and they SERM’s (Selective Estrogen Receptor Modulator)  and AI’s (Aromatise Inhibitor) . SERM’s selectively prevent the effect of estrogen in particular areas like chest and AI’s prevent the conversion of testosterone into estrogen in the first place. These are the only drugs that can interact with breast tissue and stop it from growing .
Now comes the bad part about them. SERM’s (Selective Estrogen Receptor Modulator) and AI’s (Aromatise Inhibitor) are two class of very strong drugs and they are prescribed as a last sort for treating breast cancer among women [20, 21]. They also have very strong and serious side effects making them unsafe for gynecomastia. You might wonder why these drugs with such a long list of side effects are prescribed in the first place. You have to take into consideration the fact that they are prescribed for a life threatening medical condition like breast cancer in women. In that case the side effects are justified when compared against loss of life.
AI’s prevent production of estrogen
SERM’s interrupts the effects of estrogen.
Prescribed as a last resort for breast cancer in women
Bone density loss (Osteoporosis)
Pain or pressure in the pelvis
Leg swelling or tenderness
Shortness of breath
Sudden vision problems
Since SERM’s and AI’s in their original form cannot be used safely, different combinations of natural ingredients that had similar characteristics of SERM’s & AI’s were tested by a number of companies. The formula that had the most success involved a combination of Sclareolides, Guggulsterone and Theobromine Cacao. This is current formula used by leading gynecomastia supplements like Gynexin and Gynectrol. We will take a look at the roles these ingredients play in the next part of this Gynexin review.
Sclareolide is natural product derived from various plants Salvia sclarea, Salvia yosgadensis, Salvia haematodes, Salvia plebeia, Salvia miltiorrhiza, Salvia officinalis. These herbs commonly found in the Mediterranean, North Africa and Central Asian regions. Salvia haematodes roots increase sexual behaviuor of male rats . However, Salvia miltiorrhiza increases estrogen in mice . Salvia plebeia suppresses the expressions of genes related to adipogenesis and lipogenesis activity . Salvia officinalis improves insulin sensitivity, inhibits lipogenesis in adipocytes and reduces inflammation as judged by plasma cytokines [25, 26].
Guggulsterone is natural ingredient processed from the gum of the Commiphora mukul tree. It signals the thyroid gland to produce more triiodothyronine that increases function of the thyroid gland [27,28,29] which has a direct catabolic effect on pectoral adipose tissue (chest fat) . Guggulsterone may stimulate the thyroid gland to burn more pectoral fat. Guggulsterone influence numerous steroid receptors .
Theobromine Cacao is a natural ingredient extracted from the Kola nut. Theobromine Cacao posses anti-breast cancer compounds . Theobromine Cacao has compounds, which influences in a positive way our moods and our state of alertness . These effects are due to antiradical properties of cocoa phenolics , which increase the plasma level of antioxidants to prevent the oxidation of LDL-cholesterol . These particular properties are related to the protective mechanism of cocoa phenolics in heart disease . Other relevant properties include their ability to modulate the immune response [36,37,38,39,40] and their anti-inflammatory [41,42,43] and anticarcinogenic properties .
|Ingredient||Name||Mechanism Of Action|
|1||Sclareolides||May suppress adipogenesis and lipogenesis activity, improve sexual function|
|2||Guggulsterones||May increase the function of thyroid gland, which may increase lipolysis (Burns off chest fat)|
|3||Theobromine Cacao||May modulate the immune response and has anti-inflammatory and anticarcinogenic properties|
|4||Caffeine||Enhances focus and provides energy |
|5||Chromium Picolinate||Reduce insulin resistance and to help reduce the risk of cardiovascular disease and type 2 diabetes |
|6||Green Tea Extract||Works against high-fat diet-induced obesity and type II diabetes and could reduce the risk of coronary disease |
|7||Titanium Dioxide||Has antimicrobial effect |
|9||Red Dye #40||AFC (Artificial Food Colour)|
|10||Red Dye #3||AFC (Artificial Food Colour)|
|11||Blue Dye #1||AFC (Artificial Food Colour)|
In this part of the Gynexin review, I am listing some of the frequently asked questions about Gynexin about medication conflicts, diet, workouts etc.
There are no strict diet requirements but it is recommended that you go a diet that is less in fat. This is to ensure that there is less fat available for the body and this will also help to speed up chest fat lipolysis coupled with increased metabolism. Remember that fat deposits produces the enzyme aromatase that converts testosterone to estrogen and any reduction in fat intake will give the body one less opportunity to create more estrogen.
Another improvement in your diet that you can make while taking Gynexin is to ensure that you are not limiting food items that are high in estrogen or that which promotes estrogen. Completely avoiding food items with estrogen is not possible but this is one small step that adds up to the effectiveness. Below is a list of food items that are rich in estrogen. The last three in the list have been found to lower testosterone levels. This is not by any standards a complete list of food items with estrogen and that is beyond the scope of this page. I am just giving you something to start with. I also want to make it create that avoiding these foods will not get rid of gynecomastia but together with Gynexin, it provides the body every opportunity to starve the estrogen [49,50,51].
|13||High – PUFA Vegetable Oils|
|12||Mint, Peppermint, Spearmint|